Epigenetics and Tumor Suppressor Genes
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منابع مشابه
Therapeutic Targeting of Tumorigenesis and Tumor Disease - For Clinical Analysis of Epigenetics and Epigenome
Tumorigenesis, in general, is originated from two types of gene alterations, a tumor suppressor gene and a proto-oncogene/oncogene. A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from tumorigenesis. When this gene mutates, it causes a loss or reduction in its protection[1]. A proto-oncogene is a normal gene coding proteins which regulate cell growth and differentiatio...
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The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
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Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an ex...
متن کاملSunday May 4
An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modifications in cancer cells on a gene-by-gene basis, among them the seminal finding of transcriptional silencing of tumor suppressor genes by CpG island promoter hypermethylation. Epigenetic gene inactivation i...
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تاریخ انتشار 2017